1Department of Physiology, College of Medicine, Misan University, Iraq
2Department of Surgery, College of Medicine, Misan University, Iraq
Zinc is one of an essential trace element, it has an important role in many enzymes of the body. It is less harmless in comparison with several other metal ions. Acute zinc intoxication occurs only if there is an exposure to high doses of zinc. Zinc poisoning may be mostly from dietary supplements, including multivitamins, or results from an accidental ingestion of zinc-containing household products.
The present study was designed to evaluate the histopathological changes of zinc toxicity in liver and kidney of albino mice.
Fourty-eight male Albino mice divided into four similar groups, the first three groups exposed during 15 days to different zinc concentrations in the form ZnSO4 (60 mg/kg, 80 mg/kg and 100 mg/kg) intraperitoneally. Fourth group set as a control group, treated with saline (0.9%) for the same period of intraperitoneal injection. Sections of liver and kidney were stained with hematoxylin-eosin and examined by light microscopy.
Several changes in the liver and kidneys sections like cell necrosis, congestion, swelling, disappearing of cell borders and others was observed during histopatological examination. It appears from the results that the intensity of tissues defects increased with increasing of zinc toxic concentration.
Results of study suggest that zinc may be toxic for use in mice and cause many toxicological changes in the liver and kidney.
Zinc sulfate, toxicity, mice, liver, kidney
