1Surgical Oncology Department, National Cancer Institute, Cairo University, Egypt
2Pathology Department, National Cancer Institute, Cairo University, Egypt
Many endometrial cancer patients will undergo a comprehensive lymphadenectomy despite having disease confined to the uterus with low percent of lymph node metastasis, resulting in prolonged operating time, additional cost, and potential side effects, sentinel lymph node (SLN) procedure has been evaluated in Endometrial Cancer and has emerged as a possible middle solution to overcome under treatment of high risk patients or over treatment of low risk patients.
This is a cross sectional non randomized, prospective study, non-comparative study with the purpose of determining rate of SLN detection at Egyptian National Cancer Institute, Cairo University for patients presented with early endometrial carcinoma.
46 patients have SLN using blue dye. 32 case injected with methylene blue (69.6%) and patent blue injection was in 14 cases with (30.4%). SLN was detected in 39/46 cases with detection rate (84.8%). With failure of detection in 7/46 cases with failure rate (15.2%), false-ve rate 16.7% and test sensitivity is 84.3% with NPV 97.1% and accuracy 97.4%. No false positive cases present in this study this means that False +ve rate 0%, specificity 100% and PPV 100%.
SLN using Blue dye is very simple especially in low resource countries but is associated with low detection rate and false negative rate. As surgeons gain experience in SLN mapping for endometrial cancer and achieve detection rates of 90% or greater, with a combined decrease in false-negative rates.
Blue, dye, endometrial, lymphadenectomy, lymphedema
