Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 8

Charting the Polymorphism of Angiotensin Converting Enzyme Gene in Obstructive Sleep Apnea Patients: A Case Control Study in Indian Population

  • Author:
  • Snigdha Pattanaik1,, R Rajagopal2, Neeta Mohanty3, Antarmayee Panigrahi4
  • Total Page Count: 5
  • Page Number: 367 to 371

1Associate Professor, Department of Orthodontics and Dentofacial Orthopaedics, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha

2Professor, Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai

3Professor, Department of Oral & Maxillofacial Pathology and Oral Microbiology, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha

4Associate Professor, Department of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha

*Corresponding author: Dr Snigdha Pattanaik, PhD Scholar, Saveetha Institute of Medical and Technical Sciences, Associate Professor, Department of Orthodontics and Dentofacial Orthopaedics, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha Email: dr.snigdhapattanaik@gmail.com

Online published on 26 September, 2019.

Abstract

Obstructive sleep apnea (OSA) is defined by the number of apnea and hypopnea episodes per hour of sleep (apnea-hypopnea index, AHI), reflecting the degree of departure from the normal physiology of breathing during sleep. It can be influenced by both genetic and environmental factors. From the literature it is evident that the polymorphism of ACE gene is linked to various disorders. The study aims to chart the polymorphism of the ACE gene in the OSA patients.

A total number of 100 subjects (50 OSA and 50 control) were involved in the study. ACE gene I/D allele and genotypes distribution were analyzed in both the OSA and the control group. The data collected was subjected to statistical analysis.

The study showed that there was a higher frequency of I allele in the patients with OSA. Patients with sleep apnea had a higher frequency of II genotype, compared to control group.

It is evident from the study that the higher frequency of I allele is associated with the presence of Obstructive sleep apnea. Hence, ACE gene polymorphism might be useful to ascertain the risk of developing OSA.

Keywords

Alleles, Angiotensin converting Enzyme, Genetic Polymorphism, Genotype, Renin-Angiotensin System, Obstructive Sleep Apnea,