1Ph. D scholar, Department of Biochemistry, Shri B.M. Patil Medical College, BLDE (Deemed to be University), Vijayapur
2Professor, Department of Biochemistry, Shri B.M. Patil Medical College, BLDE (Deemed to be University), Vijayapur
3Professor of Biochemistry, CAIMS, Karimnagar
4Associate Professor, Department of Biochemistry, Shri B.M. Patil Medical College, BLDE (Deemed to be University), Vijayapur
*Corresponding author: Ms. Samudrala Sangeeta, Ph. D Scholar, Department of Biochemistry, Shri B.M. Patil Medical College, BLDE (Deemed to be University), Vijayapur. E-mail id: samudralasangeeta@gmail.com
Online published on 26 September, 2019.
Chronic kidney disease (CKD) is a public health problem across the globe which is characterized by the accumulation of various substances like urea, creatinine, electrolytes, water, in the human body. CKD patients are more prone to increased risk of developing oxidative stress due to metabolic disorders, immunodeficiency and persistent infections and inflammation. Myeloperoxidase may participate as one of the mediators of oxidative modification of biomolecules/tissues and contribute to the development of co-morbidities and complications in patients with CKD.
The present study was undertaken to assess the role of Myeloperoxidase, HbA1c, Urea, Creatinine urine microalbumin and eGFR in chronic kidney disease in diabetic and non diabetic patients.
A cross sectional study consisting of two groups with 50 participants each was carried out. Group-I included 50 Chronic kidney disease patients without Diabetes mellitus (CKD-ND) & Group-II included 50 patients of Chronic kidney disease with Diabetes mellitus (CKD-DM). Myeloperoxidase, HbA1c, Urea, Creatinine and urine microalbumin were estimated in the blood and urine samples by using Erba & ELISA kits on XL-640 clinical chemistry analyzer and ELISA reader.
The values of Myeloperoxidase were statistically decreased in diabetic patients with chronic kidney disease(Group-II)when compared with Non diabetic patients with chronic kidney disease (Group-I). Myeloperoxidase levels were compared with Urea, Creatinine, Microalbumin and eGFR levels. eGFR levels showed a significant negative correlation with MPO levels.
The present study showed that decreased serum MPO can be used as an indicator for chronic kidney disease in diabetic patients which can prevent further complications. MPO levels decline steadily as CKD progresses, which might be due to the inhibitory effect of uraemic toxins on the enzyme.
Myeloperoxidase, Chronic Kidney Disease, Diabetes mellitus, Estimated glomerular filtration rate (eGFR), urine Microalbumin
