Histological Study of Hypothyroidism Induced Effect by Methimazole on Heart and Blood Vessels of Healthy Female Rabbits

The study was designed to investigate the effect of hypothyroidism induced by methimazole drug on blood vessels and heart tissues histology of female rabbit. The experiment has included twenty adult female rabbit weighing 1500–2000 gm. They were divided into two groups (10 rabbit/group) as follows. Group one (G 1) was a control group, ten female rabbits Water and regular food were given as a positive control group. Group two (G2) ten female rabbits were orally received only methimazole (0.02 mg/kg B.W). Histological sections revealed significant changes in the heart and blood vessels. Such changes include endothelium enlargement and thickening of lining of the vessel, hyperplasia, infiltration of inflammatory cells and fatty vacuoles in tissue cells.