1Physiology and Endocrinology, Collage of Medical Techniques, The Islamic University, Iraq
2Faculty of Science, University of Kufa, Iraq
3Faculty of Medicine, University of Kufa, Iraq
Online published on 26 September, 2019.
Osteoporosis is a porous bone. It is common disease of bones, and causes insufficient bone formation or loss of bone mineral density(BMD), making the bones more susceptible to fractures. The aim of the current study is to determine the role of inflammatory makers in women with osteoporosis after menopausal, this biomarkers include the; Interleukin-1β(IL-1β)and Resistin.
According to case-control study. This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province/Iraq from to know the prevalence of osteoporosis in Iraqi menopausal women. A total number of the study include (88) women involved in this studyp. IL-1β, Resistin and estrogen were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA).
In current study showed a significant decrease (p< 0.05) in level of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker show a significant increase (p< 0.05) in the concentration of IL-1β and Resistin in menopausal women with osteoporosis compared with healthy group.
In this study found the role of immunity after menopausal and relation to osteoporosis through measured the level of IL-1β and Rsisten which increase after menopausal and activation of the bone resorpation.
Resistin, Menopausal, estrogen (E2), IL-1β, BMD
