1Medical Laboratory Department, Collage of Medical Technology, The Islamic University, Iraq
2Biology Department, Collage of Science, University of Kufa, Iraq
Metabolic syndrome (MetS) is a worldwide distributed public health problem and its incident in increase. (MetS) is characterized by clustering of several metabolic abnormalities, including central (intra-abdominal) obesity, dyslipidemia, hyperglycemia, and hypertension. The ultimate importance of this cluster is to identify individuals at high risk of both type 2 diabetes and cardiovascular disease. High-mobility group box-1 protein (HMGB1) plays an important role in alarming of inflammation and immunity response processes. The aim of the current study is to evaluate the serum level of high mobility group box-1 protein (HMGB1) biomarker levels in MetS patients regarding to MetS risk factors, age, gender and BMI.
This study was conducted at Diabetes and Endocrinology Unit in Al-Sader Teaching Hospital in AL-Najaf province/Iraq from January2018 to July 2018 to know the prevalence of metabolic syndrome patients who attended the hospital for monthly checkup. A total of the (130) participant involved in this study, blood samples had been taken from the (90) metabolic syndrome patients (50 female and 40 male), and from (40) individual who were apparently healthy as a control group. The age, gender, WC and BMI of patients and control is taken during physical exam lipid profile and blood glucose also estimated for all groups. HMGB-1 protein biomarker in serum was measured by using a solid phase enzyme-linked immunosorbent assay (ELISA).
The result of the current study have revealed a significant increase in concentration of serum HMGB-1in MetS compared to healthy group. There was significant increase in the serum concentration of The HMGB-1 in Mets female group compared to in Mets male group. In regard to BMI, the results indicated a significant difference (p>0.05) in serum HMGB-1 concentration at different BMI (over and obese weight) between female and male Mets patients respectively in same the BMI. Regarding waist circumference, significant increase has been found in serum level of HMGB-1 in Mets patients
Metabolic syndrome (MetS), high mobility group box-1 protein (HMGB1), age, gender, BMI, waist circumference and lipid profile
