Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 8

The Relation between Serum Concentration of Paraoxonase-1 Enzyme with Some Criteria in Metabolic Syndrome Patients

1Medical Laboratory Department, Collage of Medical Technology, The Islamic University, Iraq

2Biology department, College of science, University of Kufa, Iraq

*Corresponding author: Arshad Noori Al-dujaili, E-mail: arshad.aldujaili@uokufa.edu.iq

Online published on 26 September, 2019.

Abstract

Metabolic syndrome (MetS) is a worldwide distributed public health problem and its incident in increase. (MetS) is characterized by clustering of several metabolic abnormalities, including central (intra-abdominal) obesity, dyslipidemia, hyperglycemia, and hypertension. The ultimate importance of this cluster is to identify individuals at high risk of both type 2 diabetes and cardiovascular disease (CVD). PON1 an antioxidant enzyme carried by HDL, it can hydrolyze lipid peroxide in lipoproteins as a result of its lipolactonase activity thereby decreasing oxidative stress in serum lipoproteins, macrophages, and atherosclerotic lesions. The aim of the current study is to evaluate the serum level of paraoxonase-1 biomarker levels in MetS patients regarding to MetS risk factors, age and gender

This study was conducted at Diabetes and Endocrinology Unit in Al-Sader Teaching Hospital in AL-Najaf province/Iraq from January2018 to July 2018 to know the prevalence of metabolic syndrome patients who attended the hospital for monthly checkup. A total of the (130) participant involved in this study, blood samples had been taken from the (90) metabolic syndrome patients (50 female and 40 male), and from (40) individual who were apparently healthy as a control group. The age, gender, WC and BMI of patients and control is taken during physical exam lipid profile and blood glucose also estimated for all groups. PON-1 enzyme biomarker in serum was measured by using a solid phase enzyme-linked immunosorbent assay (ELISA).

The result of the current study showed a significant decrease in concentration of serum PON-1in metabolic syndrome patients in compared with healthy group. The PON-1biomarker revealed a significant increase in the serum concentration in Mets female group in compared with in Mets male group respectively on the other hand the study show there is a significant difference in serum PON-1 level in Mets females patents when compared with Mets male group at same age group in (40-49y). Significantly increase in PON1of Mets female patents with WC group in (140-160cm) as compared with the male patient in the same WC while, no significant increase in serum PON-1level among other study groups.

Keywords

Metabolic syndrome (MetS), Paraoxonase-1, age, gender, BMI, waist circumference and lipid profile