1Biology Department, University of Kufa, Iraq
Coxsackievirus B (CVB) which belong to enterovirus, has been widely implicated into triggering of Type 1 Diabetes Mellitus disease through many suggested mechanisms. This study was designed to investigating and understanding the relationship between CVB infection and inducing Type 1 Diabetes disease via estimation of many parameters within patients’ serum like Anti-Glutamic acid decarboxylase autoantibody and proinflammatory cytokines (TNF-and IL-6) that induced upon CVB infection.
A case-control study included 58 of diabetes mellitus type 1 patients and 30 normal control. All patients were diagnosed according to clinical history and the patients and control subjected to estimation of (Anti-CVB IgG, Anti-Gad, TNF-α and IL-6) within serum via ELISA assay.
The frequencies of (Anti-Gad, TNF-α and IL-6) showed higher levels among T1D patients in comparison to control and these parameters revealed significant association with high level of Anti-CVB IgG among patients.
The high level of (Anti-Gad) and (TNF-α and IL-6) within CVB-T1D patients may indicated the possible role CVB viruses in the inducing autoimmunity disorder of T1D.
Coxsackievirus B, β-cells, Glutamic acid decarboxylase autoantibody, Type 1 Diabetes Mellitus, TNF-α, IL-6
