Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 8

Microbiome Alterations on Incidence Chronic Rhinosinusitis with Nasal Polyps of Indonesians

1Department of Otolaryngology Head and Neck Surgery, Medical Faculty, Hasanuddin University, Makassar, Indonesia

*Corresponding author: Amelia Dian Utami, Department of Ear, Nose, Throat, Head-Neck Surgery, Medical Faculty, Hasanuddin University, Makassar (90245) Indonesia. Email: ameliadianutami@gmail.com

Online published on 26 September, 2019.

Abstract

Affects approximately 10% of general population, leads to decrease quality of life, lost productivity as well as increase financial burden to society. Chronic rhinosinusitis with nasal polyps (CRSwNP) recognize as a benign nasal growths that usually arise as a result of chronic paranasal sinuses inflammation. Alteration of microbial composition may cause increasing the incidence of allergic disorders and contribute to the development and chronicity of inflammatory disease

Investigate histopathology of nasal polyps and nasal microbiome in chronic rhinosinusitis with nasal polyps of Indonesians

This study was conducted using the case control technique on 10 patients of CRSwNP. All of the samples examined by next generation sequencing technique and nasal polyps histopathological examination.

The non eosinophillic type is a dominant in CRSwNP while Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, Fusobacteria, and Proteobacteria were the dominant phylum in CRSwNP with variation number of percentage.

This study highlights alteration of microbial composition of CRSwNP and its histopathological examination.

Keywords

Chronic Rhinosinusitis, CRS, CRSwNP, Microbiome, Proteobacteria, Histopathology, Dysbiosis