1Kursk State Medical University, St. K. Marx, 3, Kursk, Russia, 305000
2Russian State Social University, St. V. Pika, 4, Moscow, Russia, 129226
*Corresponding Author: Zavalishina Svetlana Yurievna Russian State Social University, St. V. Pika, 4, Moscow, Russia, 129226, Phone: +79102700994, Email: svetlanazsyu@mail.ru
Online published on 26 September, 2019.
to evaluate the developmental changes in the hemostatic properties of platelets in outbred rats aged between 3 and 24 months of ontogenesis.
The study included 156 outbred healthy male rats, including 28 heads at 3 months of age, 31 rats aged 6 months, 33 heads aged 12 months, 34 animals aged 18 months and 30 rats aged 24 months. Used biochemical, hematological and statistical research methods.
The amount of lipid peroxidation products in rat platelets remained stably normal for up to 12 months, subsequently progressively increasing until the end of observation. This was due to the change in their physiological properties of catalase and platelet superoxide dismutase. Their activity in rats remained stably large until 12 months, and subsequently gradually decreased until the end of the observation. The found changes were accompanied in rats by an increase in the platelets of self-assembly of the actin-myosin complex, as well as the level of content in them and the degree of secretion from them of the ADP and ATP molecules after 12 months of age. In animals older than 1 year, an increase in the ability of platelets to aggregate was observed, which indicated an increase in their primary hemostasis.
The found gradual increase in the level of platelet activity in rats during the second year of their life indicates an increase with age of expression of fibrinogen receptor on the surface of platelets to various inducers of platelet aggregation and an increase in the activity of intra-platelet hemostatic processes.
Ontogenesis, rats, platelets, aggregation, secretion, lipid peroxidation
