Indian Journal of Public Health Research & Development

Aging is recognized as an inevitable biological process. He proved the presence of the genetic component and the environmental component. The aging process affects all organs, gradually weakening their viability and making the death of the body more and more likely. The hemostasis system, including platelets, is also involved in the implementation of the aging process. They also show signs of aging, which play an important role in the development of various pathologies with age. In the experiment in aging rats, a gradual increase in platelet aggregation properties was observed. This leads to an increase in the number of activated blood platelets in their blood and an excess of their aggregates of any size. These changes make a serious contribution to the development with age of a decrease in the reactivity and resistance of the organism, making many of the negative effects from the environment very dangerous for an aging animal. An increase in the intravascular activity of platelets in aging rats indicated an increase in the number of inducers of their aggregation in their blood and an increase in the sensitivity of platelets to them. In rats in the late stages of ontogenesis, this is accompanied by a gradual decrease in the number of inactive discoid platelet varieties in the blood. The increase in the blood of old rats of the number of different active forms of blood platelets is a consequence of the enhancement of their aggregation properties and causes the development of thrombophilia during the progression of aging.