1Department of Anesthesia and Pain Management, National Cancer Institute, Cairo University, Egypt
2Virology and Immunology Unit Cancer Biology Department, National Cancer Institute, Cairo University, Egypt
3Department of Clinical Pathology, General Organization of Teaching Hospitals and Institutes, Ministry of Health, Cairo, Egypt
*Corresponding Author: Mohamed F Shedeed, MSc Department of Anesthesia and Pain Management, National Cancer Institute, Cairo University, Egypt Phone: +201006501724 Email: Fathymohammed786@yahoo.com
Online published on 26 September, 2019.
Major surgical procedures lead to perioperative immunosuppression. This study aimed to evaluate the influence of Total intravenous anesthesia (TIVA) on the immune response of oncologic patients undergoing lower limb surgeries.
The study included 18 patients with lower limb malignancies scheduled for lower limb-sparing surgery. They were planned to receive Total intravenous anesthesia (TIVA), (n=18). Pain intensity and levels of IL-6 and IL-10 were assessed postoperatively. If visual analogue scale (VAS) scores ≥ 4, a dose of morphine 2.5 mg IV was used.
In the study group, IL-6 and IL-10 levels were measured at baseline and 24 hours after surgery. Both IL-6 and IL-10 levels increased 24 hours after surgery. Increase of IL-6 level was significantly higher than that of IL-10 (p < 0.001). The total morphine consumption in TIVA was 17.72 ± 1.32 mg.
Total intravenous anesthesia (TIVA) provides effective anesthesia but does not enhance the patients’ immune response by disturbing IL-6/IL-10 balance in patients undergoing surgery for lower limb malignancy.
Total intravenous anesthesia, lower limb cancer, IL-6, IL-10, immune response
