Micro RNA 141 as a Biomarker for Ovarian Cancer

Ovarian cancer, especially ovarian carcinoma is very dangerous form of cancers that affected women and causes severe losses among them. The microRNAs or (miRNAs) are RNA transcriptsclass that commonly consisted in its length from ∼19–22 nucleotides. Those nucleotides altered the miRNA pattern that is responsible for its pathological conditions. The highly stable transcripts are miRNAs-141. Those transcripts are observed from formalin-fixed paraffin-embedded (FFPE). FFPE samples are used to identify microRNAs-141. They are usually used for the purpose of diagnosis and detection of tumors. Especially, used for detection of a very severe malignant tumor, the ovarian cancer. This study was designed for evaluation of the role of miRNA-141 and the importance of miRNA-141 patterns in FFPE samples. Those patterns were obtained from the patients suffered from ovarian cancer. The PCR-array technology was also used for the detection and the comparison of the miRNA-141 differential expression pattern of ovarian cancer. This study concluded that, the miRNA-141 can be used effectively and successfully for predication and detection of the ovarian cancer that facilitated its treatment and curing.