Angiotensin Converting Enzyme Gene Polymorphism in Hypertension Patient Detection

Hypertension is one of the important health problems in last decade in Iraqi population, high percentage of its incidence have been reported in different ages, hypertension is blood pressure which effected by different factors. The pressure of the heart does not stay at the same level at all times. It varies based on activities at a particular point in time. The present study aims to estimate Angiotensin converting enzyme gene polymorphism with Hypertension disease in females, samples collected from females had age mean 25–70 years with duration period rang 1month-15 years and BMI mean 30.30. DNA was extracted from whole blood then PCR-ARMS used to detect Deletion/Insertion sequence, results show that non-significant differences between patients and control in age and BMI, there was 45.45 of patients were obese, 42.42 were overweight while 12.12 were normal weight. Patients had age range 35–55 was more frequent it was 58.62%, while age category <35 years was 12.06% and 29.31% of patient had age >55 years. Deletion insertion genotyping was non-significant differences between study groups in all genotype (p value 0.05) the frequents of DD genotype was same for patients and control in percentages 50% with odd ratio 1. DI is more frequent in patients than control it was 25%, 22.22% respectively with odd ratio 0.1 while genotype II was high in control 27.77% and in patients was 25%.

The present results concluded that no association between ACE gene polymorphism with Hypertension disease in female of Iraqi population