Comparison between the Effectiveness of Combination of Letrozole with Misoprostol and Tamoxifen with Misoprostol in Medical Termination of First Trimester Missed Miscarriage

The missed miscarriage was similarly named as silent miscarriage. The aimed of this study was to compare the efficacy between letrozole with misoprostol and tamoxifen with misoprostol for medical termination of first trimester missed miscarriage. The study was conducted as a randomized comparative trial from January 2015 to November 2015 at Tuzkhurmatu general hospital in Salah Al-Deen government (Iraq). A total of 120 women with missed miscarriage at (6–13 weeks) gestation were randomly divided in to two groups: (60 women) were received 7.5 mg of letrozole orally for two days, and (60 women) were received 60 mg of tamoxifen for two days. After two days 600 misoprostol administrated vaginally in all women, if they had no vaginal bleeding a second dose of 800 misoprostol was given after 24 hours. The results shown that many woman prefer a less invasive way of terminating their pregnancy in case of missed abortion (and legal medical abortion), and also wish to be awake during the treatment despite the fact that they might experience more pain and longer bleeding compared with woman undergoing primary surgical evacuation and over (25%) of medically treated women undergo secondary surgical evacuation.