1College of Dentistry, Al-Bayan University, Baghdad, Iraq
*Corresponding Author: Hamsa Faisal Najim, College of Dentistry, Al-Bayan University, Baghdad, Iraq, Email: hamsa_phdmax2012@yahoo.com
Online published on 26 September, 2019.
Diabetes mellitus is a group of metabolic disorders that is characterized by elevated levels of glucose in blood and insufficiency in production or action of insulin produced by the pancreas inside the body. Current study was aimed to investigate the biochemical profiles of Iraqi obese patients with type 2 diabetes mellitus.
Fifty treated diabetic patients with type2 diabetes mellitus, twenty five newly diagnosed diabetic patients and thirty healthy individuals as control subjects were included. The biochemical analysis included measurements of malondialdehyde and glutathione in all the subjects.
Data from current study revealed highly significant increase in serum MDA in both newly diagnosed T2DM (P<0.01) and treated T2DM patients. Furthermore, serum GSH levels were significantly reduced in these groups as compared to those in control group (P<0.05). In addition, higher GSH level was observed in treated T2DM patients as compared to the newly diagnosed group (P<0.05).
Abnormally high levels of lipid peroxidation and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and oxidative stress.
T2DM. oxidative stress, anti-oxidants, MDA, GSH
