Histological Effect of the Alcoholic Extract of Nerium Oleander in the Heart and Brain in Mice and its Effect on the Lymphocytes (In Vitro)

The study consisted of two axes: 1-Knowledge of the toxic effect of leaf extract N. oleander on the histology of the heart and brain of the extract of the leaves in mice.

The plant was extracted with alcohol and the specific chemical data were calculated and the detection of some plant compounds by analytical methods. The animals were then divided into four groups. The first group was the control group, which were vaccinated with distilled water and the second group pumped the extract at a low concentration 1mg/ml and the third group dose extractor. The concentration 1.5mg/ml and the fourth group were pumped with a concentration extract of 2mg/ml. The results of the examination of the tissue of the heart for all groups for month and, edema with spasticity in the muscle cells, and fragmentation and infiltration of the cells of single-nuclei in the heart muscle. We conclude that the extract of the leaves has a toxic effect on the heart muscle. After a month of the dosage, focal necrosis was observed and in other samples of the brain samples were seen infiltration For the inflammatory cells of the nuclei and lymphocytes around volatile regions. 2-the second axis to know the effect of the extract on lymphocytes by studying extracellular (in vitro), The results of the N. oleander highly inhibitory effect on human lymphocyte mentioned.