Study of Immunological Parameters and Epidemiology Features to Rheumatoid Arthritis Frequency in Kerbala City, Iraq

Rheumatoid arthritis (RA) is one common currently disease within the world. The study exhibited relation between the elevated levels of Anti-CCP which has more specify and RF with RA disease activity.

Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Rheumatoid Factor (RF) analysis are the beast and crucial parameters for diagnosis rheumatoid arthritis because their different levels in circulated system in patients with rheumatoid arthritis about controls give important indicators for diagnosis this disease together with the symptoms.

Immunologic and demographic study including (100) samples classification in (50) patients with rheumatoid arthritis in the aging groups ranging from (>30-<50 yr.), (18) male and (32) female compare with (50) controls samples and measured levels of Anti-CCP by (CHORUS-Anti-CCP kit) based on the ELISA principle in addition to measuring RF levels by (Nephelometry kit) in the serum.

Age and gender represent risk factors, increase development of (RA) disease with aging, increase appear (RA) in female than male. Elevated Anti-CCP and RF antibodies in the serum of (RA) patients compare with healthy in Karbala city. The concentration of Anti-CCP and RF are elevated with aging, and in female more than male.