1Pathological Analysis Department, College of Health and Medical, Al-Kafeel University, Najaf, Iraq
*Corresponding Author: Ahmed Jasim Twayej Pathological Analysis Department, College of Health and Medical, Al-Kafeel University, Najaf, Iraq, Email: ahmed.twayeg@alkafeel.edu.iq
Online published on 26 September, 2019.
MDD is a common condition that afflicts the general population across a broad spectrum of ages and social backgrounds. It has been associated with inflammatory processes, including increased cytokine levels. High co-morbidity exists between MDD and chronic diseases like IR and Type 2 diabetes.
Nevertheless, the correlation between among cytokines especially IL-4 and IR parameters have not been concentrated widely in MDD. In the present study, we measured IL-4 as anti-inflammatory marker, insulin and glucose as FBS, HOMA2%IR, HOMA2%S, HOMA2%B parameters in 60 MDD patients and 40 healthy controls. Associations between cytokine levels and IR were examined.
IL-4, insulin, HOMA2%B, HOMA2%S and insulin resistance (HOMA2IR) increased significantly (p<0.05) in serum of MDD patients, in comareson with healthy controls. There is a significant correlation between FBS with IL-4 (p<0.05).
The current study introduce more confirms that major depressive patients is accompanied by activation of the immune system with significant elevations in the levels of IL-4 cytokine. These results indicate stimulation of the immune system and increased IR and modulation of IR by increased cytokine levels in MDD. The homeostatic model assessment beta-cell function (HOMA2%B) and (HOMA2%S) is strongly correlated with insulin resistance level (HOMA IR) in MDD patients.
Major depressive disorder, Interlukin-4, Insulin resistance, Homeostasis model assessment
