1Professor and Head, Department of Anatomy, Azeezia Institute of Medical Sciences and Research, Kollam, Kerala, India
2Professor and Head, Department of Anatomy, BLDEU's Shri B M Patil Medical College, Vijayapura, Karnataka State, BLDE University, Bijapur
3Professor, Department of Pharmacology, Azeezia Institute of Medical Sciences and Research, Kollam, Kerala, India
4Assistant Professor, Department of Anatomy, Azeezia Institute of Medical Sciences and Research, Kollam, Kerala, India
*Corresponding author: Prakash K G, Professor and Head, Department of Anatomy, Azeezia Institute of Medical Sciences and Research, Kollam, Kerala, India, Phone number: +9196452 16564, Mail ID: drprakashkg@gmail.com
Online published on 13 November, 2019.
Reticular activating system is increasing implicated as new target for therapeutic approaches in Parkinsonism. The objective of the present study was to evaluate the neurobehavioral effects of losartan in rotenone rat model of Parkinson's disease.
Adult Wistar albino rats were divided into four groups of six each. Parkinsonism was induced with rotenone (3 mg/Kg intraperitoneal) in three groups. One group (positive control) was treated with levodopa (12 mg/Kg) and Benserazide (3 mg/Kg). Other group (losartan group) was treated with losartan (90 mg/Kg). Motor functions were evaluated by rota rod test and spontaneous locomotor activity. Exploratory behaviour was evaluated by hole board test. Depression influences on behaviour was studied with forced swim test. Elevated plus maze test was used for analysing anxiety influences on behaviour.
The mean time of losartan pre-treated rats that stayed in the accelerating rota rod was significantly shorter compared the control, rotenone and levodopa group. Locomotor activity as measured by actophotometer was significantly decreased in the losartan group rats. The time spent by losartan group rats as immobile in water was significantly higher than the other groups. Losartan group rats had significantly higher number of head dipping in the hole board test. There was no significant change in the open arm activity both in duration and in number of entries among rats treated with levodopa and losartan
Losartan improves neurobehavioral indicators in rotenone rat model of Parkinson's disease.
Angiotensin receptor blocker; parkinsonism; renin angiotensin system; behavioural study
