Impact of Vitamin D Supplementation on Anthropometric, Glycemic and Lipemic Profile in Subjects with Type 2 Diabetes: A Randomized Control Trial

Vitamin-D Deficiency is linked with pathogenesis and progression of diabetes, hypertension, and cardiovascular diseases through various vitamin-D receptors present on tissues and organs in the body. Literature suggests, vitamin-D replenishment improves concentration of lipids and insulin secretion in subjects with type-2 diabetes mellitus (T2DM) and established vitamin-D deficiency. This randomised control trial aimed to study the impact of vitamin-D3 granules on anthropometric measurements, glycemic and lipid parameters in T2DM subjects.

70 T2DM subjects of age 30-65y, having serum 25(OH)D levels <20ng/ml were randomly divided in two groups; supplementation group (n=40) receiving weekly 60, 000 IU vitamin-D3 granules for 8 weeks and the control group (n=30). The anthropometric (waist & hip circumference, BMI) and blood pressure measurements were recorded. Fasting blood samples were taken for estimation of 25(OH)D, lipid profile and HbA1c, before and after supplementation period. Analysis was done using SPSS v20 by independent and paired t-test.

The mean serum vitamin D levels of supplementation and control group were 12.1±3.3 and 10.9±3.3 respectively. After the supplementation significant rise in 25(OH)D levels was seen in supplemented group as compared to controls. A significant decrease in weight, waist-circumference, total cholesterol & LDL-C was observed in supplementation group, post intervention, while HbA1c levels decreased non-significantly.

Vitamin-D supplementation improved the anthropometric and lipid parameters among the subjects, thus suggesting a beneficial role on cardio-metabolic profile of the T2DM subjects.