The Ethanolic Extract of Ajwa Fruits inhibits Nephrotoxicity and Deterioration of Some Blood Biochemical Properties induced by Gentamicin in Male Rats

The current study was designed to assess the probable preventive influences of extract of Ajwa fruits on the renal functional performance and some biochemical parameters of the blood, so this investigation was performed in the Biology department animal house/Faculty of Education for Girls. Sixty male Albino rats of Sprague-Dawley were equally divided into four groups, each group was comprised fifteen males: the first group was(the control), that orally submitted to 0.9% normal saline solution, the second group was intraperitoneally injected with 80 mg/kg of Gentamicin, the third group was subjected to 1 mg/kg of Ajwa fruits alcoholic extract orally+80 mg/kg of Gentamicin antibiotic intraperitoneally, the last group was orally treated with Ajwa dates alcoholic extract (1mg/kg). The treatments of all laboratory animals were one time at day and continued for three weeks. Regarding the statistical analysis of study, there was a noticeable decline in the levels of erythropoietin hormone, total protein, albumin, as well as reduced glutathione(GSH) in serum, in the opposite, urea, creatinine and malondialdehyde (MDA) levels in serum were significantly raised at the group that intraperitoneally injected with Gentamicin when compared with the other groups of the experiment, the other groups, that orally given Ajwa fruits extract +gentamicin antibiotic, and the extract of Ajwa dates only, no differences were noted in these criteria in compared with control group.