1Department of Otolaryngology-Head and Neck, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya (60131), Indonesia
*Corresponding Author: Artono Department of Otolaryngology-Head and Neck, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya (60131), Indonesia (60131), Indonesia Phone: +6281999201024, Email: unairartono@gmail.com
Online published on 13 November, 2019.
Cholesteatoma is a benign lesion in chronic suppurative otitis media having the ability to induce bone around it. Bone damage is caused by osteoclasts and interleukin-1α (IL-1α).
To analyze the correlation of IL-1α with the degree of bone destruction in cronic suppurative otitis media (CSOM) patients with cholesteatoma treated mastoidectomy surgery
Prospective colectomy tissue collexatoma was taken during mastoidectomy surgery from 20 CSO patients with cholesteatoma. All tissues were processed then IL-1α was quantitatively tested with ELISA using IL-1α specific antibodies. Bone damage rates were categorized into mild, moderate, and severe degrees. Correlation of both variables was analyzed using spearman rank test (p <0.05).
The results of IL-1α in cholesteatoma tissue in 20 patients were in the range of 25.01–35.00 pg/ml (30.76 ± 2.99). The degree of bone destruction is mostly in the weight category (65%). The result of analysis of both variables use spearman correlation test (r = 0.625; p = 0.003).
There is a strong positive correlation between IL-1 and bone damage rate in CSOM with cholesteatoma.
Cholesteatoma, interleukin-1a, bone destruction, chronic suppurative otitis media
