Lipid Accumulation Product: A Simple and Useful Surrogate Marker for Glycemic control in Women with Type 2 Diabetes Mellitus

Lipid accumulation product had developed as a surrogate marker of central fat accumulation. It mirrors the combined anatomical (waist circumference) and biochemical changes(fasting serum triglyceride level) associated with excess lipid accumulation. we aimed to study the association between lipid accumulation product and glycated hemoglobin in type 2 diabetic patients.

During January 2017 to July 2018 one hundred eighty consecutive type 2 diabetic women (age 25–60 years) were enrolled in this study at Baghdad Medical city. Waist circumference, weight, height and blood pressure was measured. Fasting blood sample was analyzed for blood glucose, glycated hemoglobin and lipid profile. The Lipid accumulation product and Visceral Adiposity Index were calculated based on a published mathematical model. Statistical analysis was done by SPSS version 23.

The glycated hemoglobin was higher across the quartiles of Lipid accumulation product, the number of diabetic patients with poor glycemic control increased with the increase in Lipid accumulation product. Significant positive correlation exists between HbA1C and Lipid accumulation product. In addition, the area under the curve showed that Lipid accumulation product has a good predictive power to identify the state of poor glycemic control. Lipid accumulation product is significantly associated with glycemic control. As HbA1C evaluation is not available in daily clinical application, it is reasonable to suggest the use of LAP as a simple and indirect assessment of long term glycemic control.