1Iraqi National Cancer Research Center, University of Baghdad
2Lecturer of Gynecology and Obstetrics, College of Medicine, Misan University, Iraq
3Department of Clinical Pharmacy, Baghdad Medical City, Baghdad, Iraq
*Corresponding Author: Kawakeb N Abdulla, Iraqi National Cancer Research Center, University of Baghdad, Email: kawakeb.n.abdulla@gmail.com
Online published on 13 November, 2019.
Cervical cancer is the third most common cancer and fourth leading cause of death in women worldwide. HER belongs to family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation. HER2 expression in cervical cancer has been reported to be present in recurrent tumors and its expression is related to poor prognosis in locally advanced cervical cancer.
Study Her2 expression and its correlation with the development of cervical carcinoma.
A retrospective study was designed to involve about 30 formalin fixed paraffin embedded tissues blocks from Iraqi women with cervical carcinoma. The immunohistochemical staining was performed using anti-Her2 to evaluate the express: ion of this marker.
From the 30 formalin fixed paraffin embedded tissues blocks, 5 were positive for Her2 and 25 were negative. All the 15 normal cervical tissue blocks were negative for Her2.
A significant correlation between Her 2 and cervical cancer.
Her 2, cervix, cancer, Iraqi women, immunohistochemistry
