Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 9

The immunohistochemical Evaluation of BRcA2 Expression with HPV infection in a Group of iraqi Women with cervical carcinoma

1Iraqi National Cancer Research Center, University of Baghdad

2Lecturer of Gynecology and Obstetrics, College of Medicine, Misan University, Iraq

*Corresponding Author: Kawakeb N Abdulla, Iraqi National Cancer Research Center, University of Baghdad Email: kawakeb.n.abdulla@gmail.com

Online published on 13 November, 2019.

Abstract

Cervical cancer is the third most common cancer and fourth leading cause of death in women worldwide. There is an increased evidence of correlation between BRCA with HPV onco-proteins. Some researchers found that the E7 and E6 onco-proteins interact directly with BRCA1 in vitro and associate with BRCA1 in vivo in cultured cells.

Study BRCA2 expression and its correlation with the oncogenic HPV16 in Iraqi women with cervical carcinoma.

A retrospective study involve 30 formalin fixed paraffin embedded tissues blocks from Iraqi women with cervical carcinoma previously diagnosed for HPV infection. The immunohistochemical staining performed using anti-BRCA to evaluate the expression of both markers.

From the 30 formalin fixed paraffin embedded cervical carcinoma tissues blocks, 8 blocks were positive for BRCA expression and 22 were negative. All the normal cervical tissue blocks were negative for BRCA.

Immunohistochemical evaluation of BRCA2 expression with HPV infection in a group of Iraqi women with Cervical Carcinoma was significant.

Keywords

BRCA2, HPV17 infection, oncogene, cervix, cancer, Iraqi women, immunohistochemistry