1Biotechnology Research Center
2High Institute of Infertility Diagnosis and ART, Al-Nahrain University, Baghdad, Iraq
Online published on 13 November, 2019.
Granulocyte macrophage-colony stimulating factor (GM-CSF) are a groups of glycoprotein growth factors, which are involved in the embryonic development and implantation process.
This study aimed to found out the role of serum activin A and G-CSF on the positive implantation leading to pregnancy outcome, in the PCOS and non-PCOS women following intra-cytoplasmic sperm injection.
In this study, eighty-eight women were enrolled and divided according to the cause of infertility, into 50 PCOS women, and 38 women diagnosed as non-PCOS, the selected women were undergoing ICSI. The activin A was measured in serum at the day of oocyte retrieval, and the GM-CSF was measured in the serum at the day of embryo transfer. All women participating in this study had the β-HCG test, 12–14 days after embryo transfer.
This study concluded that, serum activin A and GM-CSF levels are valuable in predicting pregnancy outcome in infertile PCOS women than non-PCOS women.
Serum activin A, Granulocyte macrophage, Colony stimulating factor, Prediction of pregnancy outcome, PCOS, non-PCOS women, ICSI
