1Department of Periodontia, Faculty of Dentistry, Hasanuddin University, Makassar
2Department of Microbiology, Molecular Biology and Immunology Laboratorium, Faculty of Medical, Hasanuddin University, Makassar
3Department of Pedodontia, Hasanuddin University, Makassar
4Professional Program Students, Faculty of Dentistry, Hasanuddin University, Makassar
Online published on 13 November, 2019.
The process of bone remodeling will continue to occur when a balance between cell activities such as osteoblasts and osteoclasts also occurs. This process is controlled by hormones such as estrogen.
Estrogen is known to increase the process of osteoblast differentiation and bone formation so that estrogen therapy is currently considered an effective therapy in preventing bone damage. The activity of estrogen hormone is similar to phytoestrogen activity). One type of phytoestrogens is quercetin. One of the plants in nature which contains the most quercetin is Moringa oleifera.
To determine the effect of quercetin obtained from natural ingredients namely Moringa leaf extract to increase the number of osteoblasts as a marker for bone remodeling.
Leaf extract of Moringa oleifera plant contains many flavonoids. One of the most common types of flavonoids found in Moringa plants is quercetin. Quercetin is proven to increase bone formation by suppressing osteoclast formation and activity. Quercetin also has anti-oxidant and anti inflammatory effects.
Leaf extract of Moringa oleifera plant can increase the number of osteoblasts as a marker of bone remodeling.
Moringa leaf extract, quercetin, osteoblasts, osteoclasts, bone remodeling
