1Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, Uttar Pradesh, India.
2Department of Radiology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, Uttar Pradesh, India.
3Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, Uttar Pradesh, India.
*Correspondence Address: Dr. J.R. Keshari Assistant Professor Department of Biochemistry Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P. India. Tel: +919868341087 jiutram@rediffmail.com
Online published on 1 October, 2011.
Background
The present study was designed to measure changes in markers of antioxidant capacity (measured individually and total) following acute ischemic stroke.
Methods
The study included 80 subjects. 40 were controls and 40 were ischemic stroke patients diagnosed clinically and by CT scan of the brain. Serum vitamin E, vitamin C, superoxide dismutase, uric acid and total antioxidant capacity were estimated in all subjects.
Results
Ischemic stroke patients had significantly lower levels of vitamin E, vitamin C, superoxide dismutase and significantly higher levels of uric acid as compared to controls. Total antioxidant capacity strongly correlated with serum uric acid in cases.
Conclusion
These results suggests that estimation of vitamin E, vitamin C, superoxide dismutase, uric acid and total antioxidant capacity may used as an indirect evidence of oxidative stress induced neuronal damage in acute ischemic stroke which may be useful for monitoring and optimizing antioxidant therapy.
Antioxidants, Oxidative stress, Stroke, Super Oxide Dismutase (SOD), Vitamin C, E
