1Dept. of Biochemistry, D. Y. Patil Medical College, Khollapur, Maharashtra
2Dept. of Community Medicine S.N. Medical College, Bagalkot, Karnataka
3Dept. of Biochemistry, S.N. Medical College, Bagalkot, Karnataka
4Dept. of Biochemistry, SIMS Shimoga, Karnataka
5Dept. of Biochemistry, M.R. Medical College, Gulbarga, Karnataka, India
Online published on 1 June, 2012.
Smoking is one of the major risk factors in the genesis of coronary atherosclerosis and development of coronary heart disease. Smoking may alter normal plasma lipoprotein levels.
The present study was undertaken to compare the lipid profile between chronic smokers (Group A) and chronic smokers with myocardial infarction (Group B).
Fifty apparently healthy chronic smokers and 50 smokers with myocardial infarction were selected for the study. Fasting venous blood sample was collected in controls, in AMI patients sample was collected before any intervention, and total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C) were measured. Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald's formula. Statistical analysis was done by Z test.
The lipid profile was compared between Group A and Group B.
There was a significant rise in TC, TG, LDL-C, VLDL-C and significant decrease in HDL-C in Group B as compared to Group A.
Cigarette smoking modulates the IHD risk through gene- environment interaction and smoking increases the risk of atherosis. Further studies are required to ascertain the gene environment interaction.
Chronic smokers, Myocardial infarction, Lipid profile
