Indian Journal of Public Health Research & Development

Plasmablastic lymphoma (PBL) is a rare variant of a diffuse B-cell lymphoma that is most commonly found in the oral cavity affecting the mucosa, and so named for its blastoid morphology and immunophenotype. Oral PBL has been treated heterogeneously and well defined treatment guidelines are still lacking. It includes chemotherapy, radiotherapy, combination of both or local excision followed by radiation. Prognosis is usually poor regardless of the site of origin. The clinical course is very aggressive with most of the patients dying in the first year after diagnosis. Here we present a case who was treated with high grade lymphoma protocol, CODOX-M alternating with IVAC followed by radiotherapy & Patient showing a good clinical response.