1Assistant Professor, Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., India.
2Assistant Professor, Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, Uttar Pradesh, India.
3Assistant Professor, Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, Uttar Pradesh, India.
Online published on 19 November, 2012.
Herbal extracts from Commiphora mukul (guggul) have been widely used in Asia as cholesterol-lowering agents, and their popularity is increasing in the United States. Recently, guggulsterones, the purported bioactive compounds of guggul, have been shown to be potent antagonists of 2 nuclear hormone receptors involved in cholesterol metabolism, establishing a plausible mechanism of action for the hypolipidemic effects of these extracts.
The present study is being undertaken with the aim of detecting the lipid lowering effect of the Guggul preparation in cases of hyperlipidemia.
40 patients of hyperlipidaemia both male& female were taken for this study and percentage changes in levels of lipid profile are directly measured after at 10 weeks and 12 weeks of therapy.
Gugull has beneficial effect on lipid profile. It causes statistically significant lowering of serum triglyceride and serum cholesterol and LDL, VLDL levels at the 10th week and these levels were maintained even at the 12th week of therapy.
It can be concluded that this compound can definitely be of help in lowering serum triglyceride and serum cholesterol levels in cases of I.H.D. and Diabetes mellitus. It may be recommended for primary and secondary prevention of CAD.
CVD, Guggulipid, Hypolipidemia, Hyperilipidemia, Lipid profile
