To Study the Local Anesthetic effect of Lidocaine and Ropivacaine on Reflex Movements of Nostrils in Rabbits

Local administration of Lidocaine and Ropivacaine cause reversible loss of sensory perception in the body without loss of consciousness or the impairment of central control of vital functions, especially of pain in a restricted area of the body.

Local anesthetics block the initiation and propagation of action potentials by preventing the voltagedependent increase in Na+ conductance. Though they exert a variety of non-specific effects on membrane function, their main action is to block sodium channels. Here we have to compare the local anesthetic effect of individual drug, that means identify the onset and duration of action of lidocaine and Ropivacaine.