Indian Journal of Public Health Research & Development
  • Year: 2014
  • Volume: 5
  • Issue: 3

Role of Anti-Cardiolipin Antibodies in Recurrent Spontaneous Abortions

1Assistant Professor, Pathology, Santosh Medical College & Hospital, Ghaziabad

2Associate Professor, Ophthalmology, Santosh Medical College & Hospital, Ghaziabad

3Resident, Obstetrics and Gynecology, Santosh Medical College & Hospital, Ghaziabad

*Corresponding author: Prachi Kumar, B2-004, Ananda, Apartments, Sector-48, Noida, India. E-mail: kumarprachi@yahoo.co.in ph.: Mobile No. 9958657744

Online published on 24 June, 2014.

Abstract

Anti-cardiolipin antibodies are autoantibodies which may be associated with unexplained recurrent abortions.

To evaluate the role of anti-cardiolipin antibodies in unexplained, recurrent abortions.

A cohort of 28 females with recurrent spontaneous abortions were studied for anti-cardiolipin antibodies by ELISA. 20 normal fertile age matched females served as controls.

25% cohorts were positive for anti-cardiolipin antibodies. They also had increased frequency of the antibody (35%) as compared to primary aborters (12.5%). All healthy controls were negative. All positive cases were either moderately or weakly positive for the antibody by ELISA.

Anti-cardiolipin antibodies may be associated with spontaneous recurrent abortion. It should be tested in all cases of recurrent miscarriages.

Keywords

APA (Anti-Phospholipid Antibodies), AC Lab (Anti-Cardiolipin Antibodies), ELISA (Enzyme Linked Immunosorbant Assay), APLS (Anti-Phospholipid Syndrome).