1II yr PG Student, Department of Biochemistry, ESIC MC & PGIMSR, Rajajinagar, Bangalore
2Associate Professor, Department of Biochemistry, Sapthagiri Institute of Medical Sciences & Research Centre, Chikkasandra, Bangalore
3Professor & Head, Department of Biochemistry, ESIC MC & PGIMSR, Rajajinagar, Bangalore
4Associate Professor, Department of Paediatrics, ESIC MC & PGIMSR, Rajajinagar, Bangalore
*Corresponding author: Suresh D R, No. 3/1, seethappa layout 5th Block, Doddabommasandra, Vidyaranyapura post, Bangalore-560097. Email: drsuri77@yahoo.com
Online published on 6 November, 2014.
Hypercholesterolemia & Hyperhomocysteinemia are known risk factors for atherosclerosis. Although Protein S deficiency along with Hyperhomocysteinemia are associated with arterial thrombosis precipitating stroke & myocardial infarction, very few paediatric cases have been reported so far. We report such a rare case of Stroke associated with hypercholesterolemia, homocysteinemia & Protein S deficiency in a young boy.
A 16 yrs young boy presented with left sided weakness & deviation of lips to right side. On examination he was found to be overweight (BMI - 25.1) & had left hemiparesis with 7th cranial nerve palsy (upper motor neuron type). Laboratory investigations revealed hypercholesterolemia (267mg/dl) with elevated LDL (201mg/dl) levels. Serum Homocysteine levels were mildly elevated 33 μmol/l (Normal range: 3- 17 μmol/l) and protein S level was 17% (Normal range: 77- 143%). All other investigations relevant to stroke were within normal limits.
We emphasize the importance of measuring protein S levels along with serum Homocysteine levels as predisposing factors for arterial thrombosis especially in young children for better management of stroke & other thrombotic episodes.
Hypercholesterolemia, Homocysteinemia, Protein S deficiency, Stroke
