1Final Year Postgraduate Student, Department of Biochemistry, ESIC Medical College & PGIMSR, Rajajinagar, Bangalore
2Associate Professor, Department of Biochemistry, Sapthagiri Institute of Medical Sciences & Research Centre, Chikkasandra, Bangalore
3Professor & Head, Department of Biochemistry, ESIC Medical College & PGIMSR, Rajajinagar, Bangalore
*Corresponding author: Suresh D R, No.3/1, Seethappa Layout, 5th block, Doddabommasandra, Vidyaranyapura post Bangalore-560097. Email: drsuri77@yahoo.com, drsuri77@rediffmail.com
Online published on 6 November, 2014.
Subclinical Hypothyroidism (sHT) is characterized by normal serum free thyroxine concentrations with elevated serum thyroid-stimulating hormone concentrations. It has been associated with atherosclerotic cardiovascular disease. The present study was conducted to determine the significance of Ischemia modified albumin (IMA) as a novel marker of atherosclerosis in sHT patients with normal lipid profile.
50 subclinical hypothyroidism (Isolated TSH elevation) patients of either sex > 18 years and 50 age and sex matched euthyroid controls were subjected to lipid profile, Thyroid profile (T3, T4, TSH) & IMA (marker of Atherosclerosis) estimations.
It was observed that sHT patients had normal lipid profile along with normal T3 and T4 levels. Increase in TSH (26.87 ± 1.63) levels were observed in sHT patients compared to controls (p < 0.05). IMA which was expressed in Absorption Units (ABSU) was higher in sHT (0.46 ± 0.06 ABSU) compared to the controls (0.32 ± 0.026) (p<0.05).
IMA elevation with progression of sHT signifies atherosclerotic burden before the onset of dyslipidemia. This study might be helpful to plan for better optimizing levothyroxine therapy and avoid the possible future cardiovascular disease in sHT patients.
Ischemia Modified Albumin, subclinical hypothyroidism, Oxidative stress
