A Randomized Double Blind Comparative Study of Intravenous Diltiazem and Lignocaine in Attenuating Haemodynamic Stress during Laryngoscopy and Endotracheal Intubation in Western Uttar Pradesh

The procedure of laryngoscopy and endotracheal intubation frequently induces a cardiovascular stress response characterized by hypertension, tachycardia, arrhythmias and increased serum concentration of catecholamines. Our study was undertaken to evaluate and compare the influence of lignocaine and diltiazem on the cardiovascular responses to laryngoscopy and intubation. A total of sixty patients of ASA grade I or II patients, between 18 -60 years of age, of either sex, scheduled for non-cardiac surgery, were selected for the study. Baseline parameters i.e. heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded and same parameters were recorded at one minute interval till the completion of study period. The percentage change (increase or decrease) was calculated and was analyzed statistically. There was minimal change in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure after intubation in patients who were given diltiazem as compared to lignocaine and was more stable drug. We concluded that Diltiazem 0.3 mg/kg is able to attenuate the haemodynamic response better as compared to lignocaine.