1Professor, Department of Obstetrics and Gynecology, J.J.M. Medical College, Davangere
2Associate Professor, Department of Biochemistry, J.J.M. Medical College, Davangere
3Postgraduate Department of Obstetrics and Gynecology, J.J.M. Medical College, Davangere
*Corresponding author: Ramesh A C, Professor, Dept. of OBG, JJM medical College, Davangere-4. Mobile: 9448154735, Email: rameshac67@yahoo.com
To study the efficacy of Tranexamic acid in reducing blood loss during and after the lower segment Cesarean section.
A randomized, case controlled, prospective study was conducted on 200 women undergoing lower segment cesarean section (LSCS). 100 of them were given Tranexamic acid immediately before LSCS & were compared with 100 others to whom Tranexamic acid was not given. Blood loss was collected and measured during two periods. The first period was from the placental delivery to LSCS and second from the end of LSCS to 2 hours postpartum. Vital signs at time of delivery, at 1 hour & 2 hour postpartum & Apgar score at 1 min were studied in both the groups.
Tranexamic acid significantly reduced the quantity of blood loss from the the end of LSCS to 2 hours postpartum. 71.5ml in the study group versus 112.6 ml in the control group (p=0.0002). It also significantly reduced the quantity of blood loss from placental delivery to 2 hours post-partum.
360.9 ml in the study group, versus 443 ml in the control group. (p=0.0008). No complications or side effects were reported in either group.
Tranexamic acid significantly reduced the amount of blood loss during and after the lower segment cesarean section and its use was not associated with any side effects like nausea, vomiting, diarrhea & thrombosis. Tranexamic acid can be used effectively in women undergoing LSCS.
Tranexamic acid, Cesarean section, Postpartum, Antifibrinolytic
