1Assistant Professor, Department of Pharmacology, G.S.L. Medical College & General Hospital, Rajahmundry
2Professor, Department of Pharmacology, G.S.L. Medical College & General Hospital, Rajahmundry
3Assistant Professor, Department of Community Medicine, G.S.L. Medical College & General Hospital, Rajahmundry
4Senior Resident, Dept of OBG, G.S.L. Medical College & General Hospital, Rajahmundry
5Under Graduate Student, 3rd semester, G.S.L. Medical College & General Hospital, Rajahmundry
To study and compare the effect of Nebivolol 5mg once daily versus Metoprolol 100mg once daily on Blood pressure and Heart rate in patients with essential hypertension.
This is a hospital based interventional study conducted at GSL General Hospital and Medical College which included 30 patients in each group with essential hypertension. After baseline assessment, each patient was randomly allocated to 5 mg once daily dose of Nebivolol or 100 mg once daily dose of Metoprolol for a treatment period of three months. Blood pressure and Heart rate were recorded at baseline, and every 30 days during treatment period.
The baseline SBP and DBP were similar in the two groups. Both SBP and DBP decreased gradually and significantly in those upon treatment in each group. The two treatments had similar effects on the mean change from the baseline for both SBP (P<0.0001) and DBP (P<0.0001). A high proportion of responders were noted in both groups and there was no significant difference between the treatments. But fall in heart rate was significant (P<0.0001).
There was no statistically significant difference in reduction of blood pressure and heart rate with Nebivolol 5 mg and Metoprolol 100 mg, though the fall in blood pressure and heart rate from baseline was highly significant in each group.
Nebivolol, Metoprolol Succinate, Essential Hypertension
