Antibiogram of Pseudomonas Aeruginosa in a Tertiary Care Hospital in South India

The aim of the present study is to evaluate the antibiotics susceptibility pattern of Pseudomonas aeruginosa in a tertiary care hospital in South India.

It is a retrospective record based study conducted in a tertiary care hospital in rural Bangalore from December 2011 to july 2012. Various clinical samples like pus, urine, sputum, endotracheal secretions, blood and eye swab were investigated for P. aeruginosa and antibiotic sensitivity was done by standard microbiologic methods.

A total of 110 samples with positive culture for P.aeruginosa was obtained during this study period. Commonest clinical sample from which P.aeruginosa was isolated was from pus (52.7%), followed by urine (22.7%) and sputum (16.36%). The percentage of resistance to different antibiotics were: ciprofloxacin 67.27%, ofloxacin 63.64%, levofloxacin 57.28%, imipenem 24.55%, meropenem 34.54%, piperacillin 58.18%, piperacillin & tazobactum 30.9%, cefpodoxime proxetil 80%, ceftazidime 62.72%, cefoperazone 70.9%, ceftriaxone 74.54%, cefipime 69.09%, gentamicin 60%, tobramycin 54.54%, amikacin 20.9%.

Thus in the present study, it was concluded that P.aeruginosa was highly resistant to third generation cephalosporins, fluoroquinolones and monotherapy with piperacillin. Coadministartion of β-lactamase inhibitors like tazobactum has increased the sensitivity. Carbapenems like imipenem & meropenem were also found have higher antimicrobial activity against P.aeruginosa. Among aminoglycosides the organism is found to be highly sensitive to amikacin.