Department of anaesthesiology, Rama Medical College & super speciality Hospital, NH-24, Hapur, U.P., India
Vecuronium is an intermediate non depolarizing neuromuscular blocker (NMB) with onset in 3 to 5 minutes with predictable recovery time in 20 to 35 minutes and indicated in situations requiring tracheal intubation to secure and control respiration but also allow surgeon to perform surgery with ease. Intravenous lidocaine is often used to decrease hemodynamic responses to tracheal intubation. The association of NMB to local anaesthetics results in potentiation of NMB effects. The purpose of this study was to evaluate the influence of lidocaine on vecuronium pharmacodynamics determined by acceleromyography.
Hundred and Six, ASA I-II patients, aged 18 to 65 years, were randomly distributed in two groups (CG: control and LG: lidocaine). Vecuronium was given to all patients for neuromuscular block. LG received lidocaine (1.5 mg.kg-1) 3 minutes before vecuronium. Neuromuscular function was evaluated by adductor pollicis muscle response to TOF. After NMB injection, times for first TOF response (T1) to reach 0% of baseline value and recover 25% contraction height (Dur25%) were recorded.
This study has shown statistically significant differences between groups when onset of action and clinical duration of action of vecuronium between the two were compared. Onset time and clinical duration in LG were significantly higher as compared to CG.
Lidocaine associated to vecuronium has shorten the onset of Neuromuscular blockade and prolonged clinical duration of vecuronium.
ANESTHETICS, Local: lidocaine, NEUROMUSCULAR BLOCKERS: Non depolarizing: vecuronium
