Department of Anaesthesiology, J.J.M. Medical College, Davangere
*Corresponding author: Shilpashri A M, #5185, 2nd Cross, 1st Main, S.S. Layout, ‘A’ Block, Davangere-577007, Karnataka. E-mail: shilpashri.am@gmail.com, Mob: 9448871549
Online published on 27 May, 2015.
The ideal intravenous induction agents will provide hypnosis, amnesia, analgesia, muscle, relaxation without undesirable cardiac and respiratory depression and pleasantly induce anaesthesia in one arm brain circulation time and completely wears off in a few minutes.
To study the onset of action, Hemodynamic changes and untoward effects.
This clinical study was conducted in 60 ASA grade I and II. All the patients were premedicated with inj fentanyl 2μg/kg and Inj. Glypopyrolate 0.01 mg/kg. The patients were divided into 2 groups. The ‘t’ group was induced with Inj. Thiopentone 5 mg/kg and group ‘e’ was induced with Inj. Etomidate 0.3 mg/kg. The induction time, hemodynamic changes and adverse effects were studied in both the groups.
Percentage, t-test and p-values.
Induction time was faster in Etomidate group when compared to thiopentone group, Haemodynamic changes like systolic blood pressure was significantly raised in thiopentone group and there was minimal changes in Etomidate group compared to the thiopentone group after intubation. Mean heart rate was also increased in thiopentone group compared to the Etomidate group. The incidence of apnoea was more with thiopentone than Etomidate group.
We conclude that Etomidate is an effective and rapid acting induction agent with good cardiovascular stability and respiratory stability. Its side effects can be reduced to minimum by proper premedication with suitable intravenous anaesthetic techniques.
Thiopentone, Etomidate, Onset, Haemodynamics, Adverse effects
