Distribution and Antimicrobial Susceptibility Pattern of Blood Stream Pathogens in a Tertiary Care Hospital from Suburban, Mumbai

In the era of multidrug resistance it is essential to know the exact organisms causing blood stream infections (BSI) with its antimicrobial susceptibility pattern for effective management of BSI. Blood cultures from clinically diagnosed BSI cases were processed by BacT/ALERT microbial detection system. Pure isolates were identified by mini API system and antimicrobial susceptibility test was done by ATB Reader. Out of 552 blood culture samples, 81(14.67%) were culture positive. Predominant isolates were gram positive cocci (GPC) 43 (53.09%) followed by enteric gram negative bacilli (GNB) 28 (34.57%). Coagulase negative Staphylococci (CONS) 29 (35.80%) was the most significant pathogen. All the CONS were sensitive to Vancomycin and Linezolid and resistant to commonly used drugs like Penicillin 4 (13.79%), Vancomycin and Linezolid sensitivity was 100% in GPC. Among GNB 100% sensitivity was seen to Imipenem followed by Pipercillin-Tazobactam 34 (97.14%). Both GPC and GNB were multidrug resistant.

CONS was the most common organism associated with BSI. Vancomycin and Linezolid should be used as reserve drugs fort multidrug resistant GPC and Imipenem for GNB.