1Assistant Professor,
2Associate Professor,
3Professor,
*Corresponding author: Meenakshi Jindal, Assistant Professor, Dept. of Pharmacology, Muzaffarnagar Medical College, Muzaffarnagar. E.mail: drmeenakshijindal@rediffmail.com, Contact no: 9837147964
To compare tendency of different oral beta-lactam antibiotics causing AAD in paediatric population.
The study was prospective, randomized, open and parallel study conducted in paediatric OPD of tertiary hospital.
680 children in the age group of 6 months -12yrs suffering from upper respiratory tract infection [associated with tonsillitis, otitis media, sinusitis, pharyngitis] and urinary tract infection were included in the study. 80 children having diarrhoea and children's parents who refused to be the part of the study or come for the follow up were excluded. 600 children were divided into five subgroups [A - E] and children in A group was given co- amoxyclav, B group children was given cefixime, C group children was given cephalaxin, D group children was given cefpodoxime and E group children was given cefdinir. Occurrence of AAD was observed in each group for 14 days and children were called for follow up on 3 rd, 7th and 14th day.
It was observed that A group children had - 43.3%, B group children had 20%, C group children had 23.4%, D group children had 20% and E group children had 6.6% AAD.
We see all beta-lactam antibiotic are liable to cause AAD, it is more with the co-amoxyclav and cephalaxin.
AAD [Antibiotic Associated Diarrhoea]
