1Professor, Dept of Biochemistry, J N Medical College, Belgaum
2Professor & Head, Dept of Biochemistry, Navodaya Medical College, Raichur
3Professor & Head, Dept of Obstetrics and Gynecology, Navodaya Medical College, Raichur
4Professor, Dept of Medicine, RajaRajeswari Medical College, Bangalore
*Corresponding author: Dr. Sadanand B Patil Professor, Dept. of Biochemistry J.N. Medical College Nehru Nagar, Belgaum-5900010, Karnataka (India), E-mail: sanrum03@yahoo.co.in Mobile: 09448013893
Online published on 1 October, 2015.
Preeclampsia is a hypertensive disorder and is one of the most leading cause for maternal and fetal mortality in developing countries.
Objective of this study was to investigate lipid profile in women with preeclampsia, eclampsia as compared to pregnant women.
District civil hospital, Case control study.
The study comprised of 75 cases out of which 25 were normal 3 rd trimester pregnant women, 25 women in the 3 rd trimester with preeclampsia and 25 were in the 3 rd trimester with eclampsia, attending District Civil Hospital, Belgaum, Karnataka (India). Serum was used for evaluation of lipid profile: total Cholesterol, HDL-C, Triglycerides, VLDL-C, LDL-C and free fatty acid.
There was a consistent significant increase in total cholesterol, triglyceride, VLDL-C and free fatty acid in both groups as compared to pregnant controls (P< 0.001). When compared with pregnant controls, there was a consistent significant increase in LDL-C in pre-eclamptic (P< 0.05) and eclamptic groups (P< 0.001). HDL-C levels in 3rd trimester preeclamptic and eclamptic women were not significantly different as compared to 3rd trimester pregnant women.
Pregnant women who develop pre-eclampsia had impaired lipid profile due to abnormal lipid metabolism. This appears to be of immense value in understanding the pathological process of preeclampsia/eclampsia.
Lipid profile, Pregnancy, triglyceride, pre-eclampsia
