1Assistant Professor, Department of Obstetrics and Gynaecology, PSG Institute of Medical Sciences & Research, Coimbatore
2Professor, Department of Obstetrics and Gynaecology, PSG Institute of Medical Sciences & Research, Coimbatore
3Professor, Department of Medical Gastroenterology, PSG Institute of Medical Sciences & Research, Coimbatore
Online published on 1 October, 2015.
Liver disorders unique to pregnancy are Intrahepatic Cholestasis of Pregnancy (IHCP), Syndrome of Hemolysis, Elevated Liver Enzymes, Low Platelet count and Acute fatty liver of pregnancy. The present study is done to analyse the occurrence, complications, mode of delivery and the perinatal outcomes in the women affected by these liver disorders.
Medical records of the patients admitted with the above diagnosis during Jan 2008-Dec 2013 for a period of five years were retrospectively analysed.
During the time period of the study there were a total of 31 patients with liver disorders unique to pregnancy. 10 patients were with IHCP. 13 patients with HELLP syndrome. 8 patients with AFLP. Most of the women were primigravida and presented with pruritis, jaundice, and pain abdomen. Maternal complications noted were sepsis (n=9), postpartum hemorrhage and coagulopathy. Mechanical ventilation was required for 5 patients and one mother died of acute fatty liver of pregnancy. 17 patients delivered by vaginal route, while 14 women underwent caesarean delivery. All women of AFLP had vaginal delivery considering the operative and anaesthesia related risk. 7 perinatal deaths (PNM rate 0.06) noted in these women with liver disorders unique to pregnancy and 24 mothers had live births.
Aflp, hellp, intrahepatic cholestasis, maternal and perinatal complications
