The Effect of Indomethacin on the Duodenum of Albino Rats: A Histopathological Study

Indomethacin is commonly used as anti inflammatory, antipyretic and analgesic drug. Inflammation is characterized by redness, swelling, heat and pain. Indomethacin produces anti-inflammatory effects by decreasing the production of prostaglandins. Ingestion of Indomethacin may be associated with peptic ulcer formation. Present study was carried out over a period of twelve months on 16 adult Albino rats of Charles Foster strain (8 males and 8 females). The rats were randomly divided into 4 groups. Group 1^st was taken as control and the remaining three were taken as the experimental groups. Each experimental group was subjected to oral administration of Indomethacin for 1, 2 and 3 weeks in Group I, II and III respectively. Rats of each group were dissected at the end of 1^st, 2^nd and 3^rd week intervals after giving ether anesthesia. Duodenum was preserved and stained for histological examination. Height of villi, Numbers of goblet cells columnar cells and mitotic figure/HPF showed significant changes in experimental group in comparison to control group and were more pronounced in 2^nd week. Findings of the study suggest histological changes occur after administration of Indomethacin which may be due to as a response to Indomethacin induced injury in the wall of duodenum of albino rats.