Indian Journal of Public Health Research & Development
  • Year: 2016
  • Volume: 7
  • Issue: 2

Study of Adenosine Deaminase Activity in Tuberculour Pleural Effusion and other Respiratory Diseases

1Assistant Professor, Department of Biochemistry, Katihar Medical College and Hospital, Katihar

2Assistant Professor, Department of Biochemistry, Rama Medical College Hospital and Research Centre, Kanpur

3Associate Professor, Department of Physiology, Rama Medical College Hospital and Research Centre, Kanpur

Online published on 26 April, 2016.

Abstract

Pleural effusion frequently presents a diagnostic problem to establish the aetiology inspite of good history taking, through clinical, radilological, full examination of aspirated fluid and pleural biopsy. Increased level of Adenosine deaminase activity has been found to be associated with tubercular pleural effusion.

To suggest estimating the activity of ADA as a diagnostic tool in cases of pleural effusion and compare its activity between tubercular and non tubercular origin.

Biochemical, cytological and microbiology studies was done by obtaining pleural fluid by thoracocentesis in 100 patients after excluding pleural effusion cases of malignancy, transudative effusion. 84 cases were tubercular and had high level of ADA in comparison to rest of 16 nontubercular cases. At level of 50 IU/L of ADA activity test had sensitivity of 97.6%, specificity 87.5%, positive predictive value 97.6%, negative predictive value 87.5%.

ADA level > 50IU/L in pleural effusion fluid can be important investigation in diagnosis of tubercular pleural effusion cases.

Keywords

Tuberculosis, Pleural effusion, Adenosine deaminase