1Department of Biochemistry & Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, India
2Department of Environmental Science, Institute of Science, GITAM University, Visakhapatnam, India
*Corresponding author: Dr. K. Vijaya Rachel, Assistant Professor, Department of Biochemistry & Bioinformatics, Institute of Science, GITAM University, Visakhapatnam - 530 045, India, Email: rachelr68@gmail.com
Online published on 26 April, 2016.
Prevalence of Non-alcoholic fatty liver disease (NAFLD) has dramatically increased due to the rapid rise of the metabolic syndrome. NAFLD also has the potential to progress to hepatocellular carcinoma (HCC) or liver failure. A cross-sectional study was conducted on 63 liver disease patients from Visakhapatnam. All subjects underwent biochemical tests and anthropometric evaluations. Maximum respondents are from age group 41–50 years. 74.6% hail from urban areas. 55.5% cases were associated with diabetes. The abnormalities in liver function were in the following order: Bilirubin -57.1%; SGOT – 52.3%; SGPT – Males – 47.0% and Females – 100%; ALP – 34.9% and PT – 25.3%. NAFLD is strongly linked to caloric overconsumption, physical inactivity, insulin resistance and genetic factors. Multivariate analysis has shown that age, demographic location, hypertension, kidney abnormalities and diabetes were independently associated with liver diseases. Our results suggest a significant association between liver diseases and metabolic syndrome and further emphasize that metabolic syndrome is becoming closely associated with liver diseases.
Liver disease, NAFLD, Metabolic syndrome, Oxidative stress, Multivariate analysis
